ニューロン新生の分子基盤と精神機能への影響の解明 CREST 「脳と学習」領域 大隅プロジェクト

吉川研究室 研究業績

・原著論文

・和文総説

原著論文

2007年

  • Watanabe, A., Toyota, T., Owada, Y., Hayashi, T., Iwayama, Y., Matsumata, M., Ishitsuka, Y., Nakaya, A., Maekawa, M., Ohnishi, T. Arai R, Sakurai, K, Yamada, K, Kondo, H, Hashimoto, K, Osumi, N, Yoshikawa, T.. (2007). Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biol 5, e297.

2006年

  • Ide M, Ohnishi T, Murayama M, Matsumoto I, Yamada K, Iwayama Y, Dedova I, Toyota T, Asada T, Takashima A and Yoshikawa T. 2006. Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. Journal of Neurochemistry (in press).

  • Shimizu H1,5, Iwayama Y2,5, Yamada K2,5 Toyota T2,5, Minabe Y3,5, Nakamura K3,5, Nakajima M2,5, Hattori E2,5, Mori N3,5, Osumi N4,5, Yoshikawa T2,5. Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. Schizophrenia Research. (in press)

  • Nakatani N1,8, Hattori E1,8 Ohnishi T1,8, Dean B2,8, Iwayama Y1,8, Matsumoto I3,8, Kato T4,8, Osumi N5,8, Higuchi T6,8, Niwa S7, 8, Yoshikawa T1,8. Genome-wide expression analysis detects eight genes with robustalterations specific to bipolar I disorder: relevance to neuronal network perturbation. Human Molecular Genetics. (in press)

2005年

  • Arai M, Obata N, Kockelkorn TJP, Yamada K, Toyota T, Haga S, Yoshida Y, Ujike H, Sora I, Ikeda K, Yoshikawa T and Itokawa M. 2005. Lack of association between polymorphisms in the 5' upstream region of the DISC1 gene and mood disorders. Psychiatric Genetics. (in press)

  • Arai M, Yamada K,Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T and Itokawa M. 2005. Association between polymorphisms in the promoter region of the sialytransferase 8B (SIAT8B) gene and schizophrenia. Biological Psychiatry.
    PubMedへ

  • Iwayama Y, Nakajima M, Hashimoto K, Toyota T, Yamada K, Shimizu E, Itokawa M, Hoshika A, Iyo M and Yoshikawa T. 2005. Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes. Neuroscience Letter.
    PubMedへ

  • Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Ohara K, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa S, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N,Numachi Y, Itokawa M and Okazaki Y. 2005. Genome-wide high density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p. 14q, and 20p. American Journal Human Genetics.
    PubMedへ

  • Meerabux J, Iwayama-Shigeno Y, Sakurai T, Ohba H, Toyota T, Yamada K, Ruby Nagata R, Irukayama-Tomobe Y, Shimizu H, Yoshitsugu K, Ohta K and Yoshikawa T. 2005. Association of an orexin 1 receptor 408Val variant with polydipsia- hyponatremia in schizophrenics. Biol Psychiatry 58. 401-407.
    PubMedへ

  • Iwamoto K, Bundo M, Nakatani N, Yoshikawa T and Kato T. 2005. Altered RNA editing of serotonin 2C receptor in a rat model of depression. Neuroscience Research 53: 69-76.
    PubMedへ

  • Kato T, Iwayama-Shigeno Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S and Yoshikawa T. 2005. Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia. Mol. Psychiatry. 10. 1045-1055
    PubMedへ

  • Ide M, Yamada K, Toyota T, Iwayama-Shigeno Y, Ishitsuka Y, Minabe Y, Nakamura K, Hattori N, Asada T, Mizuno Y, Mori N and Yoshikawa T. 2005. Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease. Human Genetics. 117. 520-527.
    PubMedへ

  • Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, Nakamura K, Shimizu E, Itokawa M, Mori N, Iyo M, Yoshikawa T. 2005. Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in shizophrenia and D-serine levels. Biol Psychiatry 57, 1493-1503.
    PubMedへ

  • Meerabux JM, Ohba H, Fukasawa M, Suto Y, Aoki-Suzuki M, Nakashiba T, Nishimura S, Itohara S, Yoshikawa T. 2005. Human netrin-G1 isoforms show evidence of differential expression. Genomics 86, 112-116.
    PubMedへ

  • Aoki-Suzuki, M., Yamada, K., Meerabux, J., Iwayama-Shigeno, Y., Ohba, H., Iwamoto, K., Takao, H., Toyota, T., Suto, Y., Nakatani, N., et al. (2005). A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biol Psychiatry 57, 382-393.
    PubMedへ

  • Iwayama-Shigeno, Y., Yamada, K., Itokawa, M., Toyota, T., Meerabux, J. M., Minabe, Y., Mori, N., Inada, T., and Yoshikawa, T. (2005). Extended analyses support the association of a functional (GT)(n) polymorphism in the GRIN2A promoter with Japanese schizophrenia. Neurosci Lett 378, 102-105.
    PubMedへ

  • Meerabux, J. M., Iwayama-Shigeno, Y., Sakurai, T., Ohba, H., Toyota, T., Yamada, K., Nagata, R., Irukayama-Tomobe, Y., Shimizu, H., Yoshitsugu, K., Ohta, K. and Yoshikawa, T. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenics. Biol Psychiatry (in press)

2004年

  • Ebihara, M., Ohba, H., Kikuchi, M., and Yoshikawa, T. (2004). Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene. Gene 325, 89-96.
    PubMedへ

  • Horiuchi, Y., Nakayama, J., Ishiguro, H., Ohtsuki, T., Detera-Wadleigh, S. D., Toyota, T., Yamada, K., Nankai, M., Shibuya, H., Yoshikawa, T., and Arinami, T. (2004). Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders. Biol Psychiatry 55, 40-45.
    PubMedへ

  • Toyota, T., Yoshitsugu, K., Ebihara, M., Yamada, K., Ohba, H., Fukasawa, M., Minabe, Y., Nakamura, K., Sekine, Y., Takei, N., et al. (2004). Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B. Hum Mol Genet 13, 551-561.
    PubMedへ

  • Nakatani, N., Aburatani, H., Nishimura, K., Semba, J., and Yoshikawa, T. (2004). Comprehensive expression analysis of a rat depression model. Pharmacogenomics J 4, 114-126.
    PubMedへ

  • Arai, M., Itokawa, M., Yamada, K., Toyota, T., Haga, S., Ujike, H., Sora, I., Ikeda, K., and Yoshikawa, T. (2004). Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals. Biol Psychiatry 55, 804-810.
    PubMedへ

  • Itokawa, M., Kasuga, T., Yoshikawa, T., and Matsushita, M. (2004). Identification of a male schizophrenic patient carrying a de novo balanced translocation, t(4; 13)(p16.1; q21.31). Psychiatry Clin Neurosci 58, 333-337.
    PubMedへ

  • Yamada, K., Iwayama-Shigeno, Y., Yoshida, Y., Toyota, T., Itokawa, M., Hattori, E., Shimizu, H., and Yoshikawa, T. (2004). Family-based association study of schizophrenia with 444 markers and analysis of a new susceptibility locus mapped to 11q13.3. Am J Med Genet B Neuropsychiatr Genet 127, 11-19.
    PubMedへ

  • Ide, M., Muratake, T., Yamada, K., Iwayama-Shigeno, Y., Iwamoto, K., Takao, H., Toyota, T., Kaneko, N., Minabe, Y., Nakamura, K., et al. (2004). Genetic and expression analyses of FZD3 in schizophrenia. Biol Psychiatry 56, 462-465.
    PubMedへ

  • Yamada, K., Nakamura, K., Minabe, Y., Iwayama-Shigeno, Y., Takao, H., Toyota, T., Hattori, E., Takei, N., Sekine, Y., Suzuki, K., et al. (2004). Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. Biol Psychiatry 56, 683-690.
    PubMedへ

  • Kunugi, H., Iijima, Y., Tatsumi, M., Yoshida, M., Hashimoto, R., Kato, T., Sakamoto, K., Fukunaga, T., Inada, T., Suzuki, T., et al. (2004). No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol Psychiatry 56, 376-378.
    PubMedへ

  • Fukasawa, M., Aoki, M., Yamada, K., Iwayama-Shigeno, Y., Takao, H., Meerabux, J., Toyota, T., Nishikawa, T., and Yoshikawa, T. (2004). Case-control association study of human netrin G1 gene in Japanese schizophrenia. J Med Dent Sci 51, 121-128.
    PubMedへ

  • Stork, O., Zhdanov, A., Kudersky, A., Yoshikawa, T., Obata, K., and Pape, H. C. (2004). Neuronal functions of the novel serine/threonine kinase Ndr2. J Biol Chem 279, 45773-45781.
    PubMedへ

  • Munakata, K., Tanaka, M., Mori, K., Washizuka, S., Yoneda, M., Tajima, O., Akiyama, T., Nanko, S., Kunugi, H., Tadokoro, K., et al. (2004). Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder. Genomics 84, 1041-1050.
    PubMedへ

和文総説

2005年

  • 吉川武男, 渡邊明子, 豊田倫子, 石塚祐一: マウスにおけるプレパルスインヒビションの遺伝学的解析, 分子精神医学, Vol. 5, No.2, 139-144, 2005.

  • 山田和男, 岩山佳美, 吉川武男: マイクロアレイを用いた疾患感受性遺伝子の同定, 臨床検査, Vol. 49, No.5, 509-515, 2005.

  • 糸川昌成, 吉川武男: 統合失調症関連遺伝子, 臨床検査, 印刷中.

  • 糸川昌成, 吉川武男: 統合失調症のグルタミン酸低下仮説, Clinical Neuroscience, 印刷中.

  • 糸川昌成, 吉川武男: 話題になった遺伝子多型その後-DISC1, 分子精神医学, 印刷中.

  • 吉川武男, 大西哲生: 動物モデルを用いたうつの分子遺伝学的アプローチ. 日薬理誌, 125: 25-32, 2005

  • 吉川武男: 統合失調症関連表現型の遺伝子解析?眼位異常を中心に. 脳, 21, 8: 39-43, 2005

2004年

  • 糸川昌成, 山田和男, 吉川武男: 臨床遺伝と病態理解?遺伝子研究からみた病態仮説. 医学のあゆみ, 208(3): 146-152, 2004

  • 吉川武男, 中谷紀章: 動物モデルを用いた気分障害標的遺伝子探索. 分子精神医学, 4(1): 98-99, 2004

  • 中谷紀章, 吉川武男: うつ病の病態動物モデル. CLINICAL NEUROSCIENCE, 22: 170-172, 2004

  • 服部栄治, 吉川武男: 気分障害において注目される遺伝子. 分子精神医学, 4(2): 120-125, 2004

  • 山田和男, 吉川武男: 連鎖不平衡マッピング. 生体の科学, 55: 548-549, 2004

  • 山田和男, 吉川武男: 感情障害疾患関連遺伝子の探索. 臨床精神医学, 33(10): 1321-1326, 2004

  • 吉川武男, 豊田倫子, 吉次聖志, 山田和男, 糸川昌成, 三辺義雄, 中村和彦, 都丸義郎, 武井教使, 熊倉徹雄, 森則夫: 精神疾患関連表現型の遺伝子解析. 精神神経学雑誌, 106(12): 1585-1592, 2004

  • 吉川武男: 動物モデルと遺伝子研究?動物モデルが示唆するもの. 精神神経学雑誌, 106(8): 1037-1044, 2004

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